| 학회 | 한국화학공학회 |
| 학술대회 | 2008년 봄 (04/23 ~ 04/25, 제주ICC) |
| 권호 | 14권 1호, p.533 |
| 발표분야 | 생물화공 |
| 제목 | Pathway Analysis for Succinic acid Production of Mannheimia succiniciproducens and Escherichia coli |
| 초록 | Mannheimia succiniciproducens MBEL55E is a capnophilic gram-negative bacterium which efficiently produces succinic acid. In order to analyze metabolic pathways of M.succiniciproducens, we applied elementary-mode analysis to the biochemical network of M.succiniciproducens. We then also analyzed the biochemical network of Escherichia coli, in the same way as above, in order to grasp the notable differences between these two organisms. In order to draw clear conclusions, we clustered the solutions of two microorganisms, and compared each other. Each of clusters showed characteristic yield of succinic acid and the number of solutions and clusters of M.succiniciproducens is greater than that of E.coli. This analysis can show the differences between networks of two organisms, and suggest efficient biochemical network design. [This work was supported by the Genome-based Integrated Bioprocess Project of the Ministry of Science and Technology. Further supports by the LG Chem Chair Professorship, IBM SUR program, Microsoft, and by the KOSEF through the Center for Ultramicrochemical Process Systems are appreciated.] |
| 저자 | 이상엽, 김태용, 최형록 |
| 소속 | KAIST 생명화공과 |
| 키워드 | Pathway Analysis; Mannheimia succiniciproducens; Succinic acid |
| 원문파일 | 초록 보기 |
