| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | The effect of biomolecule absoption on the fibroblast adhesion to the heparin-based hydrogel |
| 초록 | Heparin-based hydrogels were prepared by means of Michael-type addition of thiol groups of heparin to the acryl groups of poly (ethylene glycol) diacrylate. Gelation of the hydrogel was monitored using a rheometer. Depending on the crosslinking conditions, the gelation kinetics and the mechanical properties can be tuned. To enhance the cell adhesion effect to the hydrogel, various biomolecules were absorbed to the hydrogel using the heparin-binding affinity of the biomolecules. 2-D adhesion of fibroblast and 3-D adhesion of the encapsulated cells inside the hydrogel were studied in terms of the viability, the phenotype and the proliferation of the cells. Acknowledgement: Thes research was supported by a grant(code#: 05K1501-0110) from 'Center for Nanostructured Materials Technology' under '21st Century Frontier R&D Programs' of Ministry of Science and Technology, Korea. |
| 저자 | 김양중, 태기융 |
| 소속 | 광주과학기술원 |
| 키워드 | hydrogel; heparin; cell adhesion |
