| 초록 |
To provide cells with an appropriate concentration of divalent metal cations, highly regulated transporters and channels have evolved to transport these ions across the hydrophobic membranes. CorA is one of the best studied families of Mg2+ ion transporters. Recently, the X-ray crystallographic structures of CorA from Thermotoga Maritima have been determined by three research groups, and provide us with useful structural information about the transporter. However, the structures of extracellular loops in CorA, so-called the missing loops, have not been determined yet, although it has been known that the loops act as a putative selectivity filter and their sequences are highly conserved in most of Mg2+ transporters. In this study, the structures of the missing extracellular loops in the CorA Mg2+ transporter are determined by using molecular dynamics simulations (MD), and it is investigated whether the missing loops function as a selectivity filter. |
