화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터)
권호 37권 1호
발표분야 의료용고분자 부문위원회
제목 Preparation and Characterization of Rapamycin incorporated drug delivery carrier
초록 Rapamycin, also known as sirolimus, is an inexpensive immunosuppressive drug that has been well-studied in renal transplantation and in drug-eluting stents as an antiinflammatory/anti-proliferation agent. In this study, Carboxymethyl chitosan-graft-poly(ethylene glycol)-graft-Cholesterol(OCMPEGChol) was synthesized with carboxymethyl group modified Chitosan and methoxy poly(ethylene glycol) by chemical reaction for Rapamycin(Rapa) delively system. The structure were investigated by fourier transform infrared FT-IR(Fourier transform infrared), 1H-NMR(1Proton Nuclear Magnetic Resonance). Also, particle size and particle image were measured by DLS(Dynamic Light Scattering) and TEM(Transmission electron microscopy). These results to expected to shape core shell type nanoparticle.
저자 이경재, 김영민, 남정표, 박준규, 김원석, 최창용, 김명렬, 장미경, 나재운
소속 순천대
키워드 Carboxylation chitosan; Rapamycin; Sirolimus; DDS; .
E-Mail jwnah@sunchon.ac.kr