| 초록 |
FITC-doped silica nanoparticles(SiNPs) have excellent fluorescence intensity and great biocompatibility. Originally, it`s very difficult bare SiNPs enter into a live cell then have to surface modification. Therefore, these FITC-doped SiNPs have functionalized using HIV1-TAT peptides. In this study, we prepared TAT-functionalized SiNPs conjugated siRNA and TAT peptide for the purpose of improving intracellular delivery. Acknowledgments: This research was supported by No.2009-0069113, No. M20706010003-08M0601-00310 and Human Resource Training Project for Strategic Technology |
