| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Micelle Formation and Sol-gel Transition Behavior of Hyperbranched Amphiphilic Block Copolymers |
| 초록 |
Hyperbranched amphiphilic (poly((PLGA-b-PEG)MA)) and (poly((PEG-PLGA)MA)) block copolymers were synthesized by radical polymerization. (PLGA-b-PEG)MA macromonomer was prepared by ring opening bulk polymerization of DL-lactide and glycolide using purified poly(ethylene glycol) monomethacrylate (PEGMA) as an initiator. (PLGA-b-PEG)MA macromonomer was copolymerized with PEGMA and/or acrylic acid (AA) by radical polymerization to produce hyperbranched amphiphilic block copolymers. (PEG-PLGA)MA macromonomer was preapared by substituting hydroxyl end group of MPEG-b-PLGA by methacrylate group using methacryloyl chloride, and copolymerized with (PLGA)EMA. The molecular weight, chemical structure, gel-sol transition behavior, effective micelle diameter, and CMC were obtained from various methods. |
| 저자 |
박정원, 김성철
|
| 소속 |
한국과학기술원 |
| 키워드 |
drug delivery; amphiphilic polymer; micelle
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| E-Mail |
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