| 학회 |
한국공업화학회 |
| 학술대회 |
2007년 봄 (05/11 ~ 05/12, 계명대학교) |
| 권호 |
11권 1호 |
| 발표분야 |
고분자 |
| 제목 |
Evaluation of water soluble chitosan nanoparticles introduced LDL ligand by endocytosis inhibitor |
| 초록 |
we prepared using low molecular weight water-soluble chitosan nanoparticle loaded paclitaxel (WSC-NPT) and investigated the potential as a drug carrier which is able to accumulate in the tumor site. WSC-NPT was treated with sodium azid (NaN3) as an inhibitor of endocytosis process. As results, the antitumor activity of WSC-NPT treated with sodium azid didn’t show but WSC-NPT was shown the high antitumor activity. Therefore, WSC-NPs modified with hydrophobic group will be useful anticancer agent carrier via receptor-mediated endocytosis. |
| 저자 |
장민자, 허선행, 김동곤, 장미경, 나재운
|
| 소속 |
순천대 |
| 키워드 |
paclitaxel; endocytosis inhibitor; receptor
|
| E-Mail |
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