| 학회 |
한국공업화학회 |
| 학술대회 |
2007년 봄 (05/11 ~ 05/12, 계명대학교) |
| 권호 |
11권 1호 |
| 발표분야 |
고분자 |
| 제목 |
Preparation of Methotrexate incorporated polymeric micelles of methoxy poly(ethylene glycol)-grafted chitosan and its drug release |
| 초록 |
Methotrexate (MTX)-encapsulated polymeric micelle of methoxy poly(ethylene glycol) (MPEG)-grafted chitosan (ChitoPEG) copolymer was prepared by mixing of MTX/DMSO solution into ChitoPEG/deionized water. MTX-encapsulated polymeric micelle of ChitoPEG has spherical shapes particle size around 50nm at TEM observation. In 1H NMR study, the specific peaks of MTX and ChitoPEG was observed at polymeric micelle in DMSO while MPEG peaks only obtained at D2O, indicating that MTX/chitosan main chain composed of inner_core and MPEG composed of outershell. |
| 저자 |
서동혁, 정영일, 남정표, 김동곤, 나재운
|
| 소속 |
순천대 |
| 키워드 |
Methtrexate; methoxy poly(ethylene glycol); chitosan
|
| E-Mail |
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