| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
기능성 고분자 캡슐 공정 및 소재 |
| 제목 |
Drug-inorganic layered hydroxide hybrid in cancer chemotherapy: a novel strategy to suppress drug resistance |
| 초록 |
Inorganic layered double hydroxides (LDHs) are biocompatible layered materials which have attracted increasing attention as drug delivery nanovehicles. In this study, we evaluated the methotrexate (MTX)-LDH hybrid system in terms of its effects on cellular uptake, retention, and the efficacy of MTX, a well known anticancer drug, in human osteosarcoma cell lines which are MTX-sensitive and even MTX-resistant and explored the underlying mechanism for the effects. Our studies demonstrated that the efficacy of MTX against both sensitive and resistant cell lines increased significantly in MTX-LDH hybrids compared to an equivalent free MTX. Moreover, MTX-LDH hybrids considerably enhanced the cellular uptake of MTX, and well retained in both sensitive and resistant cell lines than the free MTX. The present study suggests a new mechanism for the suppression of drug resistance in tumor cells by using inorganic nanoparticle/anti-cancer drug hybrid system. |
| 저자 |
박태운1, 최진호2, 오제민1, 최수진2, 김동옥1
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| 소속 |
1(주)나노하이브리드, 2이화여자대 |
| 키워드 |
Inorganic nano capsule; anti-cancer drug
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| E-Mail |
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