| 학회 |
한국재료학회 |
| 학술대회 |
2016년 가을 (11/16 ~ 11/18, 경주 현대호텔) |
| 권호 |
22권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Poly(Amino Acid)/Squalene Nanocomplex as Vaccine Adjuvants for Enhancement of Immunogenicity |
| 초록 |
As the outbreak of infectious disease is getting more frequent and devastated year by year, the advent of more efficient anti-infectious disease vaccine is greatly expected. Therefore, the development of better vaccine adjuvant accompanied with vaccine antigen to boosting immune response for enhancing immunogenicity has been greatly required. Herein, we address nanocomplex of amphiphilic grafted poly(amino aicd) and squalene (PA/S-NC) as a strongly potent vaccine adjuvant against influenza virus. The results showed that these nanocomplex performed proper biocompatibility and stability. More importantly, intramscular co-administration of PA/S-NCs and an H1N1 pandemic strain (CA04) produced antibodies and cytokines in a conditional mouse model. Furthermore, The PA/S-NC/CA04 immunization prevented disease symptoms and protected mouse model against lethal infection with H1N1 influenza virus. Consequently, our PA/S-NC could be one of great vaccine adjuvant for enhancing vaccine-induced immune responses. |
| 저자 |
임종우1, 김현욱1, 나운성2, 염민주2, 윤다연1, 강아람2, 김지혜1, 박근선1, 천해진1, 송대섭2, 함승주1
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| 소속 |
1연세대, 2고려대 |
| 키워드 |
<P>Poly(Amino Acid); Emulsion; Vaccine; Adjuvants; Virus</P>
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| E-Mail |
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