| 학회 |
한국공업화학회 |
| 학술대회 |
2005년 가을 (10/28 ~ 10/29, 건국대학교) |
| 권호 |
9권 2호 |
| 발표분야 |
고분자 |
| 제목 |
Synthesis and Application of Thermosensitive and Biocompatible Block Copolymers with Poly(N-isopropylacrylamide), Poly(ethylene glycol ), and Poly(ε-caprolactone) |
| 초록 |
To endow polymeric nanoparticles with thermosensitive, biocompatible, and biodegradable characters, nanoparticles composed with poly(N-isopropylacrylamide-b-e-caprolactone) (PNIPAAm-PCL) and poly(ethylene glycol-b-e-caprolactone) (PEG-PCL) block copolymers were prepared with different the block copolymer compositions. The nanoparticles showed composition dependent physicochemical properties such as lower critical solution temperature, particle size, and critical aggregation concentration. Then, the nanoparticles were introduced into drug delivery systems using hydrophobic model drug of clonazepam. The temperature sensitive drug release behaviors from nanoparticles were investigated. |
| 저자 |
공병기1, 채수영1, 최창용1, 조종수2, 나재운1
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| 소속 |
1순천대, 2서울대 |
| 키워드 |
thermosensitive; biocompatible; polymeric nanoparticle
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| E-Mail |
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