| 학회 |
한국화학공학회 |
| 학술대회 |
2008년 가을 (10/23 ~ 10/24, 부산 BEXCO) |
| 권호 |
14권 2호, p.2755 |
| 발표분야 |
생물화공 |
| 제목 |
Analysis of Mannheimia succiniciproducens Physiology in Different CO2 Levels |
| 초록 |
Mannheimia succiniciproducens MBEL55E produces succinic acid in high concentrations as a fermentation end product. The cells could not grow below 8.74 mM of dissolved CO2, indicating that there is a threshold level of CO2 to sustain the growth of M. succiniciproducens. Succinic acid yield on glucose was 1.49 and 1.52 times higher at 141 mM CO2 than those obtained from 8.74 mM CO2, respectively. Through the result of enzyme activities, we focus on the efficient carboxylation of phosphoenolpyruvate (PEP) to oxaloacetate, in which CO2-fixation occurs by both PEP carboxykinase (PckA) and PEP carboxylase (Ppc), allows M. succiniciproducens to produce substantial amounts of succinic acid. [This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) (2005-01294). Further supports by the LG Chem Chair Professorship, IBM SUR program, Microsoft, and by the KOSEF through the Center for Ultramicrochemical Process Systems are appreciated.]. |
| 저자 |
최 솔1, 송효학2, 이정욱3, 김지만1, 이상엽2
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| 소속 |
1Metabolic and Biomolecular Engineering National Research Laboratory, 2Department of Chemical & Biomolecular Engineering and BioProcess Engineering Research Center, 3KAIST |
| 키워드 |
succinic acid; Mannheimia succiniciproducens; CO2
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| E-Mail |
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| 원문파일 |
초록 보기 |
