| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Bio-inspired Oxygen-generating Gelatin Adhesives for Wound Management |
| 초록 |
Mussel-inspired biopolymers have recently received considerable attention as tissue adhesives and sealants because of their strong adhesive strength in wet surfaces. Molecular oxygen (O2) has been implicated as an essential signaling molecule in the wound healing and tissue regeneration. Herein, we designed an O2-generating gelatin adhesive formed via calcium peroxide-mediated crosslinking reaction and in situ polymerization of dopamine. We demonstrate that the hydrogels rapidly generate O2 up to 70% pO2 and release O2 from hydrogels in a sustained manner (for up to 7 days in vitro). The hydrogels show controllable tissue adhesive strength (15−38 kPa) depending on dopamine concentrations. The hydrogels facilitate wound healing with enhanced neovascularization in vivo. These results suggest that the O2-generating tissue adhesive hold a great promise as tissue adhesives and sealants for wound management as well as tissue regenerative medicine. |
| 저자 |
이소희, 박경민
|
| 소속 |
인천대 |
| 키워드 |
Tissue adhesives; polymeric hydrogels; oxygen; wound management
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| E-Mail |
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