| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
Synthesis of poly(ethylene oxide) -b- poly(cyclic hydrazide) and its application for preparation of drug nanocarrier |
| 초록 |
Living anionic ring-opening polymerization of ethylene has been used for preparation of block copolymer. In this study, poly(ethylene oxide) (PEO) -b- poly(N-phenylmaleimide) was first synthesized by sequential monomer addition technique, followed by deimidation using hydrazine hydrate under the acidic condition leading to the corresponding PEO -b- poly(cyclic hydrazide). The resulting compounds were found to be very efficient to be utilized for synthesis of polymer prodrugs such as PEO-Doxorubicin and PEO-Methotraxate (MTX) conjugates. Depending on the reaction condition, those conjugates became ‘smart’ drug-nanocarriers which could be used as polymeric stabilizers or fluorescent imaging materials. In this presentation, we report the preliminary results for preparation of ‘smart’ materials to be used in the drug delivery system. |
| 저자 |
시디크아부바카, 김정안, 강호정, 이재열, 김윤, 이재혁, 양세라, 김성우, 연규상, 이유라
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| 소속 |
경희대 |
| 키워드 |
poly(ethylene oxide); drug nanocarrier
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| E-Mail |
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