| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Anti-fouling Effects of Dendritic Poly(ethylene oxide)s on Cell Surfaces |
| 초록 |
Poly(ethylene oxide)(PEO) polymers are non-toxic, water soluble, chemically stable, and resistant to immune response that have potential applications in biomedical field. The introduction of PEO into the dendritic structure, it has different structure, for example smaller hydrodynamic volume and spherical shape, may has additional advantages compared to linear PEO. Dendritic PEOs were synthesized by living anionic ring opening polymerization of ethylene oxide. Dendritic PEOs were synthesized by divergent method and each generation was carried out in THF using diphenylmethyl potassium (DPMK) catalyst. Allyl bromide was introduced to polymeric chain ends and dihydroxylation was carried out for branch point. All generations were characterized by 1H NMR spectroscopy and GPC. Coverage effects of dendritic PEOs on solid materials are confirmed by AFM images and protein adsorption. After modification on cell surfaces, dendritic PEOs were shown effective anti-fouling properties. |
| 저자 |
김주은1, 정지헌1, 변영로1, 김정안2, 안철희1
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| 소속 |
1서울대, 2경희대 |
| 키워드 |
anti-fouling; PEO; dendritic
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| E-Mail |
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