| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
콜로이드·계면화학_포스터 |
| 제목 |
Analysis of nanoscale intermolecular interactions between polyhexamethylene guanidine and model cell membranes |
| 초록 |
A variety of antibiotics, toxicants or antimicrobial compounds interact with the biofilm and require accurate assessment of molecular interactions and bioavailability of existing or newly synthesized molecules. In this study, Surface force apparatus (SFA) measurements and Langmuir trough based tensile measurements are performed to reveal the molecular interaction mechanism with the model membrane to assess the biotoxicity of potential toxic compounds. Polyhexamethylene guanidine (PHMG) was selected as a toxic compound because PHMG contained in the humidifier disinfectant caused many victims in S. Korea due to lack of comprehensive evaluation of PHMG toxicity and interaction mechanism in biofilm. Using SFA and LB tensile measurements, we have shown that only PHMG exhibits strong interactions with biological membrane interfaces and has demonstrated the potential to use this method as a new toxicity testing method. |
| 저자 |
박진우1, 임찬웅1, 박소희2, 고진아1, 황동수2, 이동욱1
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| 소속 |
1울산과학기술원, 2포항공과대 |
| 키워드 |
surface; surface force apparatus; membrane; interface
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| E-Mail |
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