| 초록 |
To make chitosan derivatives with improved hydrophilic and antifungal characteristics, some attempts have been taken for 1,3-diazole derivatives coupled polysaccaride like azolic aldehyde onto chitosan-NH2 while keeping the fundamental skeleton of chitosan more or less intact. Recently, the reaction of chitosan with phosphorus pentoxide by this method was found to give water-soluble phosphoric chitosan (P-chitosan) of sufficiently high degree of substitution (DS). In the present study, we aimed to prepare ketoconazole derivative coupled to water-soluble chitosan and it's phosphate chitosan derivatives. And investigate their activity behavior and spectrum. |
