| 초록 |
Klebsiella oxytoca naturally produces a large amount of 2,3-butanediol (2,3-BD), especially (2R,3S)-BD. K. oxytoca strain is recognized as a GRAS (generally regarded as safe) microorganism. The U.S. National Institutes of Health (NIH) Guidelines have noted that K. oxytoca belongs to RG 1, indicating that it is safe to handle (http://www.absa.org/). We engineered metabolically K. oxytoca strain for enhanced production of 2,3-BD. Recently, we found out that 2,3-BD, especially (2R,3S)-BD, has excellent antiseptic, antimicrobial, and moisturizing properties. This implies that (2R,3S)-BD can be used for cosmetics, personal cares, and home cares. In the present study, we carried out a number of tests, such as patch response test and MIC test, by using (2R,3S) rich-BD to determine its potential applicability. These results strongly suggest that (2R,3S) rich-BD produced by microbial fermentation can be used for cosmetics, personal cares, and home cares. [This work was supported by the Biochemical Industry Promoting Technology Development Project (No. 10050407) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea).] |
