| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
(여성인재육성)행동하는 여성-“에너지, 환경, 소재”-여성이 하면 “확” 다르다 |
| 제목 |
Ru-complex와 이중나선, 사중나선 DNA와의 상호작용 연구 |
| 초록 |
Interactions of the ruthenium complexes with various nucleic acids have been widely investigated for their potential biological applications. This type of studies recently expanded for the G-quadruplexes and only a few reports started to appear. In this study, interaction of a set of enantiomer namely, Δ-, Λ-[Ru(phen)2DPPZ]2+ with human telomeric DNA, 5´-G2T2G2TGTG2T2G2-3´(15-mer), which forms a G-quadruplex in the presence of potassium ion was investigated by various spectroscopic techniques. The well-known enhancement of luminescence intensity (the ‘light-switch’ effect) was also observed for the [Ru(phen)2DPPZ]2+ when form an adduct with the G-quadruplex. The luminescence of the G-quadruplex bound Ru(II) complex can be quenched by external quencher. The [Ru(phen)2DPPZ]2+ complex bind at the lateral loop or under the diagonal loop and the other bind the side of the G-quadruplex. |
| 저자 |
이영애 |
| 소속 |
영남대 |
| 키워드 |
DNA; Ru-complex; G quadruplex; Light Switch effect
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| E-Mail |
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