| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Endothelial reactivation of Etv2/Er7 induced tumor angiogenesis and impaired tumor angiogenesis by siRNA nanoparticle |
| 초록 |
Angiogenesis, new blood vessel formation from preexisting vessels, is critical for solid tumor growth. Here, we demonstrate that the developmentally critical transcription factor Etv2 is selectively upregulated in both human and mouse tumor associated endothelial cells (TAECs) and is required for tumor angiogenesis. Etv2 deficient TAECs displayed decreased Flk1 (Vegfr2) expression, FLK1 activation, and proliferation. Endothelial tube formation, proliferation, and sprouting response to vascular endothelial growth factor was reduced in Etv2 deficient ECs. Systemic administration of Etv2 siRNA nanoparticles potently inhibited tumor growth and angiogenesis without cardiovascular side effects. Targeting the ETV2 pathway might offer opportunity for selective anti-angiogenic therapies. |
| 저자 |
Ashraf Ul Kabir1, Tae-Jin Lee2, Hua Pan3, Suk Ho Bhang2, Kyunghee Choi1
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| 소속 |
1Washington Univ. School of Medicine, 2Sungkyunkwan Univ., 3Univ. of South Florida |
| 키워드 |
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| E-Mail |
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