| 초록 |
Extracellular matrix (ECM) is a complex but highly organized network of macromolecules that plays a critical role in cell adhesion, migration, and differentiation. While the effects of individual ECM component, i.e., collagen, fibronectin, or laminin have been well documented, the real face of a physiologically relevant ECM is much less understood, due mainly to the lack of proper resource and limited enabling technology. To address such issue, we have investigated the impact of cell-derived ECM (CDM) that is obtained from in vitro-cultured cells via decellularization process. This naturally derived self-assembled CDM-based enabling technology is introduced in this talk. We physically combine biocompatible polymer and CDM together and eventually develop an ECM patch that seeks advanced tissue repair, including cardiovascular, skin wound, and cornea. We envision a new class of therapeutic patches based on natural ECM toward regenerative applications. |
