| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Sequential Delivery of Growth Factor for Enhanced Osteogenesis of hMSCs by using Hydrogel Micropattern-incorporated Fibrous Scaffodls |
| 초록 |
In this study, we fabricated multi-functional 3D fibrous scaffolds which have capability of independently-controlled release of BMP-2 and bFGF. The fibrous structure was obtained via electrospinning, and the blend of polycarprolactone and gelatin was used as the material of fiber matrix. To create patterned structure which consists of poly (ethylene glycol) hydrogel and fiber. The resultant micropatterned 3D fibrous scaffold offered not only biomimetic structures but also suitable biochemical environment for cell differentiation by releasing two growth factors independently from hydrogel and fiber, respectively. Results showed that the sequential release system of 3D fibrous scaffolds was beneficial to induced osteogenesis of hMSCs, and the efficiency was higher than other released systems with or without single growth factors. The fabricated multifunctional 3D fibrous scaffold indicates the potential for using practical tissue engineering. |
| 저자 |
국윤민, 고원건, 한상원, 조강희, 차성호, 방혜정
|
| 소속 |
연세대 |
| 키워드 |
Scaffolds; Osteogenesis; Micropattern; Growth Factor; MSC
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| E-Mail |
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