| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Inducing Differentiation of Myoblast Using Aligned Nanofiber Incorporated Poly(ethylene glycol) Hydrogel Micropatterned Scaffolds |
| 초록 |
In this study, we fabricated 3D fibrous scaffolds to promote myogenic differentiation of myoblast. We used poly (ethylene glycol) (PEG) hydrogel and polycaprolactone (PCL) electrospun nanofiber to create micropatterned structure. The resultant micropatterned 3D fibrous scaffold had random, parallel, vertical orientation of nanofiber and hydrogel. This scaffold offered not only biomimetic structures but also suitable environment for cell differentiation by cell morphology change. The results showed that the aligned fibrous network and hydrogel structure of 3D scaffolds were beneficial to induce myogenesis of myoblast, and efficiency was higher than other systems without alignment of nanofiber or hydrogel. The fabricated multifunctional 3D fibrous scaffold indicates the potential for using practical tissue engineering. |
| 저자 |
홍혜진, 국윤민, 민지홍, 한상원, 고원건, 차성호
|
| 소속 |
연세대 |
| 키워드 |
scaffolds; PEG; PCL; electrospinning; myogenesis
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| E-Mail |
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