| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Characterization and Improved Dissolution on Solid Dispersions of Domperidone Maleate |
| 초록 |
Domperidone is an antidopaminergic drug. Clinically, domperidone is widely utilized to treat gastrointestinal disease such as chronic gastritis, gastroesophageal reflux disease of adults and infantile cyclic vomiting syndrome and repiratory tract infection. The goal is to improve the dissolution rate of domperidone maleate. Solid dispersions were prepared by spray-drying method with polymer. All solid dispersions were analyzed by SEM, FT-IR, XRD and DSC. In vitro dissolution behavior of solid dispersions was carried out in gastric juice (pH 1.2) and these results were compared with model drug. The dissolution rate of all solid dispersions was improved due to influence of polymers. This study suggests that the content of polymers added in solid dispersions can affect the dissolution behavior and change dissolution rate of drug. This research was supported by WCU (R31-20029). |
| 저자 |
조선아, 이정환, 김민정, 윤현, 심초록, 고현아, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
domperidone maleate; polyvinylpyrrolidone; solid dispersion; spray drying
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| E-Mail |
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