| 초록 |
Recently, hydrogels have been intensively researched as controllable carriers of drugs in the pharmaceutical industry. Because the hydrogels are made up of cross-linked hydrophilic polymers containing a significant amount of water in their networks, they are applicable to various biomedical areas. In this study, a novel hydrogel system was found which utilizes a drowning-out crystallization system: Whole aqueous dispersion of atorvastatin (ATV) crystals crosslinked with polyacrylic acid (PAA). XRD results show that this combined process of crosslinking and crystallization made the drug amorphous. Also, PAA controlled the crystal growth of atorvastatin. As a result, the particle size of drug was reduced. In a gel state, elastic modulus (G′) was higher than viscous modulus (G″). Atorvastatin in the hydrogel carriers shows sustained release patterns. |
