| 초록 |
Stimuli-responsive nanomaterials have been utilized to control the release kinetics of drugs while minimizing unwanted drug leakage from nanocarriers in drug delivery system. Among them, N-isopropylacrylamide (NIPAM) is well known as a thermo-responsive polymer and used as an intelligent component together with a pyrogenic agent. GNP is well known as a plasmonic material with excellent optical properties. The light absorption wavelength of small GNPs can be tuned to the near-infrared (NIR) region through their reshaping. Here, we present a simple method to synthesize overgrown plasmonic gold nanogels (O-PGNs) through the overgrowth of the GNPs in the pNIPAM hydrogel. To induce the overgrowth of GNP inside the polymer, we simply added hydroxylamine and polyvinylpyrrolidone dropwise. Then, Drug release was tested using doxorubicin in presence of external light stimulation. In addition, the biocompatibility of the O-PGN was investigated with human fibroblast, and effective drug release to cancer cells was confirmed under the NIR condition. We believe that the developed O-PGN will be an nanocarrier for enhancing drug delivery efficiency in vivo. |
