| 초록 |
For the tissue engineering scaffold, it is very important to create electrospun polymeric scaffolds with specific mechanical and biological properties similar to native ECM because randomly electrospun fibers could physically mimic the nano-scaled ECM structure of native tissues. In this study, we investigated the effect of added gelatin into electrospun PLCL fibers on biocompatibility and mechanical properties of the nano- to micro-sized fibers. The fiber diameter of PLCL/gelatin was decreased with increasing gelatin content. Fibers containing 10 - 30 wt % gelatin demonstrated an enhanced tensile strength with still high elongation at break, which was attributed by compatibility of PLCL and gelatin in some extent. Also, a significantly improved cell proliferation was observed only from PLCL 90/gelatin 10 fibers. Such an enhanced effect of gelatin, both on mechanical strength and cytocompatibility of PLCL/gelatin fibers, would be very preferable for tissue engineering scaffolds. |
