| 초록 |
In this study, we prepared a hybrid scaffold using biomass-based synthetic and natural polymers, an anionic waterborne polyurethane (WPU) and gelatin, respectively, via a freeze-drying technique to prepare a substitute for tissue engineering. In order to examine the various properties of the synthesized WPU/gelatin hybrid scaffold, we carried out scanning electron microscopy (SEM), contact angle measurement, zeta potential analysis, Fourier-transform infrared spectroscopy (FT-IR), dynamic mechanical analysis (DMA), in vitro biodegradation tests, water uptake, and cellular interaction using dermal fibroblast. The results indicated that the pore distribution was greatly homogeneous and interconnected, in addition, the mean pore diameter of these scaffolds were uniformly ranged from 150 to 300 µm. Moreover, as the amount of WPU increased, both storage moduli and tensile strength evidently grew. Accordingly, these fabricated WPU/gelatin hybrid scaffolds has potential application for tissue regeneration. |
