| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Novel synthetic polymer Via Enzymatic polymerization between Isosobide and Glutamic acid |
| 초록 |
A novel polymer (ISE) based on renewable isosorbide was prepared by reacting with a various ratios of isosorbide and L-glutamic acid via a one-step esterification using enzymatic catalyst, novozyme 435. The successful synthesis of the ISE was confirmed by 1H nuclear magnetic resonance, and its molecular weight was ranged from 6,000 to 14,000 g/mol. Its potential for application in biomedical field was investigated through evaluation of gene transfection efficiency. Although weak gene condensation activity and transfection efficiency were showed due to primary amines of glutamic acid, we proposes that ISE may be utilized as polymeric backbone for gene carrier if it was introduced into cationic materials and targeting ligands. This work (Grants No. C0276732) was supported by Business for Cooperative R&D between Industry, Academy, and Research Institute funded Korea Small and Medium Business Administration in 2015. |
| 저자 |
박영훈1, 장미경1, 박성철1, 김영민1, 이종완2, 김남홍3
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| 소속 |
1순천대, 2KTR, 3아이씨케미칼 |
| 키워드 |
polymerization; gene delivery system; Biopolymer
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| E-Mail |
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