| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
대학원생 구두발표 (영어발표, 발표15분) |
| 제목 |
Evaluation of EGFR targeting cetuximab conjugated temozolomide loaded poly (lactic-co-glycolic acid) nanoparticles for the treatment of cancer. |
| 초록 |
Overexpression of the epidermal growth factor receptor (EGFR) is known to accelerate the growth of cancer cells. In this study, cetuximab (Cmab) conjugated temozolomide (TMZ) loaded poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs), termed Cmab-TMZ-PLGA NPs was developed to target EGFR overexpressing cancer cells. TMZ loaded PLGA NPs (TMZ-PLGA NPs) were prepared by the emulsion solvent evaporation method. Cmab was conjugated to PLGA-NPs by EDC/NHS cross-linking chemistry. The mean particle size of Cmab-TMZ-PLGA NPs was 162.26 ± 5.09 nm with spherical surface morphology. Further study showed that Cmab-TMZ-PLGA NPs have higher cellular uptake, higher cytotoxicity, higher apoptotic effect, and upregulated γ-H2A.X expression than TMZ-PLGA NPs and free TMZ in U-87MG, SW480 and SK-Mel 28 cancer cells. Thus, Cmab-TMZ-PLGA-NPs offer a versatile nanoplatform to treat EGFR overexpressing cancers. |
| 저자 |
ramesh duwa1, Simmyung Yook2
|
| 소속 |
1College of Pharmacy, 2Keimyung Univ. |
| 키워드 |
Cetuximab; Epidermal growth factor receptor; Nanoplatform; Poly (lactic-co-glycolic acid); Temozolomide
|
| E-Mail |
|
