| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Acellular surface-modified scaffolds for delivery of nephron progenitor cell for renal tissue regeneration |
| 초록 |
In recent year, renal tissue regeneration with the help of extracellular matrix (ECM) derived scaffold is expected to be a promising strategy. Extracellular matrix (ECM) derived scaffold owing to its highly biocompatiblity and ability to guid renel tissue regeneration. In our previous study, magnesium hydroxide nanoparticles incorporated three dimensional porous PLGA scaffold was directly coated with fibroblast derived extracellular matrix. Inspired from previous study, here we have prepared nephron progenitor cell containing ECM surface- modified scaffolds for renal tissue regeneration. In in vitro cell studies with NPCs, modified scaffold showed improved cell viability and significantly increased growth factor release in respective time. An 8-week post implantation study conducted on kidney model demonstrated that modified scaffold reduced the expression of fibrogenesis inducing cytokine marker and accelerated the renal tissue regeneration with a low inflammatory response. |
| 저자 |
정윤기1, 김윤아1, Md Lemon Hasan1, So Young Chun2, Seung Kwon You3, Tae Gyun Kwon2, 한동근4, Won-Gun Koh5
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| 소속 |
1한국과학기술(연), 2Kyungpook national Univ., 3Korea Univ., 4Cha Univ., 5Yonsei Univ. |
| 키워드 |
Extracellular matrix; nephron progenitor cell; tissue regeneration
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| E-Mail |
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