| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
PPG(polypropyleneglycol)-PCL(polycaprolactone) of micellar characterization as drug carrier |
| 초록 |
PPG is a polymer that is structurally closely related to PEG. PPG is less hydrophilic than PEG. And Poly(ε-caprolactone)(PCL),a biodegradable polyester, is an attractive polymer which can be used as a synthetic biomaterial due to its good biodegradability and biocompatibility. Here we describe the preparation of PCL-PPG-PCL triblock copolymer by ROP of CL from the hydroxyl end group of PPG in the presence of HCl·Et2O as a monomer activator. Their unique molecular structure can make them form polymeric micelles in an aqueous medium. The hydrophobic PCL segments of the block copolymers form the inner core of the micelles, whereas the hydrophilic PPG segments form the outer shell of the micelles. These micelles seem to be potential carriers for drug delivery, because the hydrophobic biodegradable core may serve as a hydrophobic drug reservoir and the PPG shell covalently linked to hydrophobic core can greatly increase the micelle stability in the biological environment. |
| 저자 |
이상효1, 손진수1, 김재일1, 권두연2, 강휘주1, 이봉2, 한동근3, 김재호1, 김문석1
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| 소속 |
1아주대, 2부경대, 3KIST |
| 키워드 |
PPG; micelle; caprolactone
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| E-Mail |
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