| 초록 |
Although 5-fluorouracil (5-FU) has been used in clinical chemotherapy for the treatment of advanced breast cancer, colorectal cancer and adenocarcinomas of the gastrointestinal tract, it also has strong side effects such as high incidences of toxicity in the bone marrow, gastrointestinal tract, central nervous system and skin. In this study, a new monomer conjugated with 5-fluorouracil, 4-aminosalicylic acid which is widely valued for their analgesic, antipyretic and anti-inflammatory properties was synthesized, characterized and polymerized directly via atom transfer radical polymerization (ATRP) to obtain higher antitumor activity and lower toxic side effects mentioned above. The in vitro cytotoxicities of 5-FU and the synthesized monomer and polymers were evaluated with mouse mammary carcinoma (FM3A), mouse leukemia (P388), and human histiocytic lymphoma (U937) as cancer cell lines and mouse live cells (AC2F) as a normal cell line. |
