| 초록 |
Light has been used for triggering hydrogelation since it allows spatiotemporal control. Conventional systems utilize UV/visible light and photoinitiator. However, due to limited tissue penetration and phototoxicity of UV/visible light, NIR light-based hydrogelation system was studied. Also, to reduce amount of cytotoxic initiator, thiol-acrylate reaction was used. It is a radical-mediated step-growth reaction between thiol and acrylate groups, which is specific and efficient. Also, life time of radicals can be promoted. Thus, hydrogels can be formed with lower concentration of initiator. In this study, we developed NIR light-assisted thiol-acrylate hydrogelation system including gold nanorod (GNR) and thermal initiator. Conversion of NIR light energy into thermal energy that generating free thiyl radicals for thiol-acrylate reactions, results in hydrogels. The effects of thiol groups on gelation process were studied and in vivo formation of the hydrogels was demonstrated. |
