| 초록 |
Polysaccharide is one of the widely used natural polymers in many biomedical applications due to its excellent biocompatibility. Hyaluronate-based hydrogels are typically prepared in the presence of excipient chemical reagents. In this presentation, it will be discussed how hyaluronate hydrogels can be prepared without toxic chemical cross-linking agents for cartilage regeneration. In brief, alginate, derived from brown seaweed, was introduced to the hyaluronate backbone, allowing the gel formation in the presence of calcium ions. In addition, a biomimetic system to culture mesenchymal stem cells (MSCs) using cell-instructive alginate hydrogels will be discussed. Chondrogenic differentiation of MSCs cultured within hydrogels was influenced by using a peptide derived from E-cadherin receptor. This approach may find useful applications in 3-D stem cell culture and tissue regeneration. |
