| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Image-Guided Prostate Tumor Therapy using Aptamer Functionalized TCL-SPION |
| 초록 |
We report CG-rich duplex containing prostate-specific membrane antigen (PSMA) aptamer conjugated thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) as prostate cancer-specific nanotheranostic agents that are capable of prostate tumor detection in vivo by magnetic resonance imaging (MRI) and selective delivery of drugs to the tumor tissue, simultaneously. The prepared PSMA functionalized TCL-SPION via hybridization method (Apt-hybr-TCL-SPION) exhibited preferential binding towards target prostate cancer cells (LNCaP, PSMA+) in both in vitro and in vivo when analyzed by T2-weighted MRI. After Dox molecules loaded onto the Apt-hybr-TCL-SPIO, the resulting Dox@Apt-hybr-TCL-SPION showed selective drug delivery efficacy in the LNCaP xenograft mouse model. These results suggest that Dox@Apt-hybr-TCL-SPION has potential for use as novel prostate cancer-specific nanotheranostics. |
| 저자 |
유미경1, 김동규1, 이인현1, 소지수1, 정용연2, 전상용1
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| 소속 |
1광주과학기술원, 2전남대 |
| 키워드 |
prostate cancer; magnetic resonance imaging (MRI); superparamagnetic iron oxide nanoparticles (SPION); aptamer; targeted drug delivery; theranostic agent
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| E-Mail |
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