| 초록 |
Boron neutron capture theraphy (BNCT) was first proposed as a potential cancer theraphy in 1936 but the successful application of BNCT to the treatment of cancer still presents a challenge in medical research. BNCT is a binary therapy, which is dependent on the selective deposition of 10B in the tumor prior to irradiation by thermal neutrons. The combination of 10B and thermal neutron produces 2.4 MeVmol-1 enough to destroy the tumor cells. We herein report on the synthesis of bis{bis(2-methoxyethyl)amino)carboranes as potential BNCT agents. In vitro studies showed that the desired bis{bis(2-methoxyethyl)amino)carboranes accumulate to high levels in B-16 melanoma cells despite low cytotoxicity. |
