화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터)
권호 42권 2호
발표분야 기능성 고분자
제목 pH-sensitive drug delivery system based on modified mesoporous materials with Poly-l-lysine(PLL) as a gate keeper
초록 Silica nanoparticles are an attractive material as a building block for the design of smart-delivery systems because there are large surface area and pore volumes, favourable biocompatibility, inertness to chemicals, and porous structures that can be tailored to the desired applications. In this work, we have investigated the synthesis and characterization of functionalized mesoporous silica nanoparticles(MSN) with a biopolymer. The surface of the silica was modified with (3-aminopropyl)triethoxysilane (APTES). Afterwards, mesoporous silica nanoparticles were capped with poly-L-lysine (PLL) containing two amino groups. This polymer was used a gate keeper for MSN. The structure and surface properties of the mesoporous silica nanoparticles(MSNs) and modified MSNs were studied by means of XRD, N2 adsorption/desorption (BET), TGA analysis, UV–vis and FTIR spectroscopies. TEM confirmed these results and showed a coating of Poly-L-lysine on the surface MSNs.
저자 이남경, 김보경, 박성수, 하창식
소속 부산대
키워드 mesoporous silica nanoparticles; drug delivery system; poly-L-lysine
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