| 학회 |
한국화학공학회 |
| 학술대회 |
2014년 가을 (10/22 ~ 10/24, 대전 DCC) |
| 권호 |
20권 2호, p.1543 |
| 발표분야 |
생물화공 |
| 제목 |
Microbial production of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) using metabolically engineered Escherichia coli |
| 초록 |
Bio-based Polyhydroxyalkanoates(PHAs) has great interest because of their unique characteristics, biodegradable and biocompatible thermoplastic. Among lots of PHA copolymers, poly(3-hydroxybutyrate-co-3-hydroxyvalerate)[P(3HB-co-3HV)] is one of the important copolymers because of lower melting point and much better flexible compared to current used in many application. So far, for the production of P(3HB-co-3HV), adding of auxiliary carbon source was needed. However, due to the toxicity of auxiliary carbon source, it is hard to maintain the balance between cell growth and P(3HB-co-3HV) production. Thus, we developed the E. coli can stably synthesize 3HB-CoA and 3HV-CoA in controlled ratio from glucose.[The Technology Development Program to Solve Climate Changes from National Research Foundation of Korea(Development of systems metabolic engineering platform technologies for biorefineries; NRF-2012-C1AAA001-2012M1A2A2026556) and Intelligent Synthetic Biology Center(2011-0031963) of Korea through the Global Frontier Research Program of the Ministry of Education, Science and Technology(MEST).] |
| 저자 |
양정은1, 최용준2, 박시재3, 이승환4, 이상엽1
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| 소속 |
1KAIST, 2한국원자력(연), 3명지대, 4한국화학(연) |
| 키워드 |
poly(3-hydroxybutyrate-co-3-hydroxyvalerate); polyhydroxyalkanates
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| E-Mail |
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| 원문파일 |
초록 보기 |
