| 초록 |
Mytilus edulis foot protein allows a marine mussel to attach on a variety of substrates. The molecular basis of the adhesion is largely due to a catechol moiety. Catechol is also found in byssal threads, in which it acts as a cohesive molecule. Herein, we synthesized hyaluronic acid-catechol (HA-catechol) conjugates by mimicking the mussel adhesive protein. Like in nature system of the mussel, our HA-catechol conjugates had dual properties; adhesive to the variety of substrates and cohesive to each other forming hydrogel. The functionality was switchable by an external stimulus such as pH. Utilizing bio-specific interaction between HA and neural stem cell, our HA-catechol conjugates can be applied to develop functional 2D surfaces and 3D hydrogels for culture and transplantation of neural stem cells. A biopolymer with dual properties is a new concept in material sciences, so we expect our research contribute on the development of tissue engineering materials. |
