| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Enhancement of cell proliferation inside a heparin-based hydrogel by fibrinogen addition |
| 초록 |
A heparin-based hydrogel was prepared by crosslinking via multiple Michael-type addition reactions between two components, thiol-modified heparin and poly (ethylene glycol) diacrylate (PEG-DA). Gelation of the hydrogel was measured by using a rheometer and completed within 20 minutes. By controlling the crosslinking condition, the gelation kinetics and the mechanical properties including swelling ratio of the hydrogel can be adjusted. NIH/3T3 fibroblast cell encapsulation using this hydrogel revealed the non-toxicity of the present system. Cell proliferation inside this heparin-based hydrogel was observed, and it was significantly (more than 5 times) by fibrinogen addition into the hydrogel during gelation. Acknowledgement This research was supported by a grant (code #: 06K1501-01520) from 'Center for Nanostructured Materials Technology' under '21st Century Frontier R&D Programs' of MOST, Korea. |
| 저자 |
최원일, 김미혜, 태기융
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| 소속 |
광주과학기술원 |
| 키워드 |
heparin; hydrogel; fibrinogen; cell proliferation
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| E-Mail |
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