| 초록 |
We herein introduced highly pH-sensitive probe from fluorescent carbon dot containing the near-infrared (NIR) heptamethine cyanine molecule IR825 for rapid bacteria detection along with subsequent killing activity via photothermal effect. IR825-loaded fluorescent carbon dot (I-CD) showed strong interaction with negatively bacterial surface, exhibiting fluorescence ON/OFF under a wide range of pH. In acidic and basic conditions, zwitterion structure is activated, losing its hydrophobicity at pH 7.4 and releasing IR825, which were responsible for NIR-sensitively photothermal activity. The release of IR825 contributed to high thermal conversion, killing 99% of bacterial cells. Hence, this material shows its potential to be used as a rapid, highly sensitive fluorescent bacterial biosensor with low-cost and for detection and effectively antimicrobial effect via photothermal conversion with pH and NIR triggers. This work was supported by Korea National University of Transportation in 2018. |
