| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
Korea-Japan Joint Symposium: Sustainable Plastics and Biopolymers (영어발표) |
| 제목 |
Injectable Polypeptide Hydrogels with Stimuli-responsiveness for Biomedical Applications |
| 초록 |
Genetically engineered polypeptides with stimuli-responsiveness have been studied as advanced biomaterials for biomedical applications because both precisely controlled amino acid sequence and monodisperse molecular weight could provide finely tuned biophysical property as well as environmental responsiveness while immunogenicity and biocompatibility could be optimized at the amino acid sequence. We report herein that injectable polypeptide hydrogels with stimuli-responsiveness were developed by temperature-triggered physical crosslinking of (1) elastin-based polypeptide (EBP)-calmodulin (CalM) fusion proteins and (2) EBP-resilin block copolymers for in vivo applications. Especially, the EBP-CalM fusions showed multiple responsiveness when bound to specific ligands while the the EBP-resilin block copolymers having high resilient property coupled with elasticity. Dynamic hydrogelation in response to multiple stimuli would be potential for functional tissue engineering. |
| 저자 |
임동우1, 이재상2, Aamna Basheer3, 강민정4
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| 소속 |
1Department of BioNano Engineering and Department of Bionanotechnology, 2Hanyang Univ., 3ERICA Campus, 4Department of Bionanotechnology |
| 키워드 |
Injectable hydrogels; Polypeptides; Stimuli-responsiveness; Drug Delivery System; Tissue Engineering
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| E-Mail |
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