| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
PEGylated TRAIL/Hyaluronic Acid Nanocomplexes as the Potential Therapeuticsfor Rheumatoid Arthritis |
| 초록 |
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been considered as a promising therapeutics for treatments of tumors and arthritis. However, its instability in the biological fluids has limited its clinical applications. In this study, we have prepared a novel type of stable, nano-sized ionic complexes consisting of PEGylated TRAIL and hyaluronic acid (HA). The particle size and zeta potentials of the complexes were significantly dependent on the feed ratio of PEGylated TRAIL and HA. The cytotoxicity of nanocomplexes was evaluated in the HCT-116 cell line using the MTT assay. Pharmacokinetics of PEG-TRAIL from nanocomplexes was measured using the ELAIS kit after subcutaneous injection of the complexes into the rat. Also, the therapeutic effect of the complexes on collagen II-induced arthritis in mice was evaluated. |
| 저자 |
김유정1, 김성호2, 채수영2, 박재형1, 이강춘2
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| 소속 |
1경희대, 2성균관대 |
| 키워드 |
TRAIL; hyaluronic acid; PEG; Rheumatoid arthritis
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| E-Mail |
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