| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
BIOCOMPATIBLE POLY(2-HYDROXYETHYL METHACRYLATE)-B -POLY( L -HISTIDINE) HYBRID MATERIALS FOR PH -SENSITIVE INTRACELLULAR ANTICANCER DRUG DELIVERY |
| 초록 |
A series of synthetic polymer bioconjugate hybrid materials consisting of poly(2-hydroxyethyl methacrylate) (p(HEMA)) and poly( L- histidine) (p(His)) are synthesized by combining atom transfer radical polymerization of HEMA with ring opening polymerization of benzyl- N -carboxy- L -histidine anhydride. The resulting biocompatible and membranolytic p(HEMA)25-b-p(His)n (n = 15,25,35, and 45) polymers are investigated for their use as pH-sensitive drug carrier for tumor targeting. Doxorubicin (Dox) is encapsulated in nanosized micelles fabricated by a self-assembly process and delivered under different pH conditions. Antitumor activity of the released Dox is assessed using the HCT116 human colon carcinoma cell line. The p(HEMA)-b-p(His) hybrid materials are capable of self-assembling into nanomicelles and effectively encapsulating the anti cancer drug Dox, which allows them to serve as suitable carriers of drugs for improved cancer chemo therapy. |
| 저자 |
렌지스1, 정영일2, 최은지1, 정정욱1, 강대환2, 오세옥1, 서홍석1, 김일1
|
| 소속 |
1부산대, 2합성고분자생물접합하이브리드재료사업단 |
| 키워드 |
Atom Transfer Radical Polymerization (ATRP); Ring Opening Polymerization (ROP); self-assembly
|
| E-Mail |
|
