| 초록 |
The challenge for current photodynamic therapy (PDT) is efficient treat cancers at a deep tissue level. The photosensitizers (PSs) used in conventional PDT are mostly activated by UV or visible light, which cannot pass through thick tissue due to the light absorption and scattering by biological tissues. The application of these UV or visible light PSs is limited to treating tumors on or just under the skin or on the lining of internal organs or cavities and is less effective when treating large and deep-seated tumors. However, Near-infrared (NIR) light is referred to as the ‘‘optical window” of the biological tissues due to the minimal light absorption and scattering. Compared with the UV or visible light, NIR shows larger penetration distance in tissue, lower photodamage effect and higher signal-to-noise ratio. Herein, the NIR triggered upconversion nanoparticles (UCNPs) based nanomedicines were synthesized. They have potential for large and deep-seated tumors treatment. |
