| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Novel Injectable Hydrogel Based on Strong Micelle Packing Mechanism |
| 초록 |
Pluronic F127 is a conventional biomaterial for injectable hydrogel by its temperature responsive sol-gel transition due to a micelle packing mechanism. However, its application as a therapeutic carrier is limited due to low stability and poor mechanical properties in in vivo application. In this study, strong supramolecular complex is introduced to improve the rheological properties and enhance drug and protein binding affinity. Modified F127 polymer forming supramolecular assembly makes strong bond between micelles. Resulted injectable hydrogel showed significant increase of rheological properties comparing to conventional F127 based gel. The hydrogel showed much higher storage modulus and enhanced stability comparing ordinary F127 based hydrogel. This hydrogel maintain its original volume more than 100 days which is a lot longer than normal F127 hydrogel which dissolves in 1~2 days. Thus, this novel injectable hydrogel is a potential candidate as stable biomolecules carrier. |
| 저자 |
심성보1, 안철희2, 이승용3, Muhammad R4, Haque1, 변영로2, 정지헌3
|
| 소속 |
1Research Institute of Advanced Materials (RIAM), 2Department of Materials Science and Engineering, 3College of Engineering, 4Seoul National Univ. |
| 키워드 |
injectable; hydrogel; supramolecular
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| E-Mail |
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