| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
PLGA microsphere/alginate system of dual growth factor delivery for stem cell differentiation |
| 초록 |
While the pivotal role of growth factors on stem cell differentiation has been widely known, it is believed that continuous release of growth factors may not be enough to elicit a maximized differentiation potential of stem cells and therefore a temporally and/or spatially controlled release system is definitely required. In this study a dual growth factor delivery system that exhibits a temporal release of individual growth factor is being realized using PLGA microsphere and alginate hydrogel. Once PLGA microspheres are manufactured using W1/O/W2 double emulsion method, they are then subjected to a micro-encapsulation in alginate by applying electric field. With each growth factor enclosed, the efficacy of dual delivery system will be evaluated using stem cells. This study can provide a basic understanding of how stem cells respond to individual growth factors that are delivered in a temporally controlled manner from dual release system. |
| 저자 |
최동훈1, 박철호1, 한동근1, 김익환2, 박귀덕1
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| 소속 |
1한국과학기술(연), 2고려대 |
| 키워드 |
alginate; PLGA microsphere; dual delivery system; stem cells
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| E-Mail |
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