| 초록 |
A wide variety of contact lenses for vision correction or eye protection after ocular surgery have been developed. However, most contact lenses cause insufficient lubrication and moisture to the eyes because they are worn directly on the eye surface. Here, we fabricated a contact lens with highly increased water content by adding hyaluronate (HA) with poly(2-hydroxyethyl methacrylate) (pHEMA). To introduce HA in contact lens, cholesteryl HA was synthesized by adding a hydrophobic cholesterol group into HA to bind with contact lens material. Then we successfully developed a contact lens containing Cholesteryl HA. Due to the hygroscopic and viscoelastic properties of HA, the amount of water contents in the contact lens was increased, thereby improving the stability of the tear film on the cornea and providing a comfortable fit. Contact lenses with cholesteryl HA showed higher water content than the pHEMA contact lenses, and their effects were confirmed through animal experiments. |
