| 초록 |
Catechol-modified hyaluronic acid (HA-CA) hydrogel has shown highly adhesive and biocompatible properties, which are beneficial in cell transplantation. Here, we synthesized HA-CA hydrogel and evaluated its efficacy in stem cell transplantation, especially for bone and cartilage regeneration. When human adipose-derived stem cells (hADSCs) were encapsulated with bone morphogenetic protein 2 (BMP-2) in the hydrogel, osteogenic differentiation of hADSCs was greatly improved, and ultimately, in vivo bone regeneration was significantly facilitated in a critical-sized calvarial defect mouse model. In addition, adhesive property of HA-CA hydrogel allowed for efficient and stable retention of cells on the decellularized trachea matrix, which would enhance cartilage regeneration in vivo. This study was supported by a grant (2016R1A5A1004694) from Translational Research Center for Protein Function Control (TRCP) funded by the Ministry of Science, ICT and Future Planning (MSIP) of Korea. |
